Much-loved Tuolumne Meadows (8,600 feet; 2,621.3 meters) is the largest subalpine meadow in the Sierra Nevada. During the Ice Age this region lay buried under 2,000 feet [609.6 meters] of ice, and all the features you see—ponds, domes, horned peaks—were carved by glaciers. Today, meandering creeks and the Tuolumne River help flood the meadows in June. By July there are blossoms of wildflowers, such as Indian paintbrush and cinquefoil. Stop in at the Tuolumne Meadows Visitor Center (+1 209 372 0263. Mem. Day-late Oct.), a hub from which hiking trails radiate into the high country.
As you leave, look northward to Lembert Dome (T32), another piece of glacial sculpture. After 2 miles [3.2 kilometers] the road parallels the boulder-strewn Dana Fork of the Tuolumne River (T34). At T36 you have a clear view of Mount Dana (13,053 feet; 4,115.7 meters) and Mount Gibbs (12,764 feet; 3,890.5 meters), whose metamorphic rocks are often tinged with alpenglow in the evenings.
At Tioga Pass (9,945 feet; 3,031.2 meters) the road crests the state’s highest auto pass, and you leave Yosemite National Park. Continue on Rte. 120 past glacially carved Ellery Lake. Now the road begins a plunge down Lee Vining Canyon. Six miles [9.7 kilometers] along, the road runs between moraines—ridges of rocky debris left by passing glaciers—that stand as high as 700 feet [213.4 meters]. Stop for information at the Inyo National Forest Ranger Station (+1 760 873 2529). The route ends in just over a mile [1.6 kilometers] at U.S. 395 and Mono Lake, a haunting body of water that is 700,000 years old and studded with spires of white tufa.